Mark Pines Selected Research

febrifugine

6/2021	Differential Effects of Halofuginone Enantiomers on Muscle Fibrosis and Histopathology in Duchenne Muscular Dystrophy.
7/2019	Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy.

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Mark Pines Research Topics

Disease

38	Fibrosis (Cirrhosis) 06/2021 - 06/2002
15	Neoplasms (Cancer) 01/2015 - 05/2002
10	Muscular Dystrophies (Muscular Dystrophy) 06/2021 - 11/2008
6	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 06/2021 - 04/2010
6	Dysferlinopathy 01/2020 - 01/2013
6	Liver Cirrhosis (Hepatic Cirrhosis) 08/2015 - 04/2004
4	Inflammation (Inflammations) 01/2016 - 02/2008
4	Hepatocellular Carcinoma (Hepatoma) 06/2006 - 09/2002
3	Hypoxia (Hypoxemia) 08/2015 - 09/2008
3	Prostatic Neoplasms (Prostate Cancer) 02/2007 - 05/2002
3	Pathologic Constriction (Stenosis) 05/2006 - 09/2004
2	Disease Progression 03/2013 - 01/2011
2	Colitis 01/2012 - 09/2004
2	Crohn Disease (Crohn's Disease) 01/2012 - 09/2004
2	Wilms Tumor (Wilm's Tumor) 02/2007 - 10/2005
2	Necrosis 02/2007 - 05/2002
1	Hypertrophy 01/2020
1	Alcoholic Fatty Liver 08/2015
1	Starvation 01/2015
1	Malaria 01/2015
1	Autoimmune Diseases (Autoimmune Disease) 01/2015
1	Breast Neoplasms (Breast Cancer) 01/2015
1	Leukemia 01/2015
1	Melanoma (Melanoma, Malignant) 01/2015
1	Osteosarcoma (Osteogenic Sarcoma) 01/2015
1	Multiple Myeloma 06/2012
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2012
1	Vitamin D Deficiency 07/2011
1	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 07/2011
1	Rickets (Rachitis) 07/2011
1	Candidiasis (Moniliasis) 01/2011
1	Renal Cell Carcinoma (Grawitz Tumor) 09/2008
1	Cicatrix (Scar) 06/2008

Drug/Important Bio-Agent (IBA)

39	halofuginoneIBA 06/2021 - 05/2002
16	CollagenIBA 10/2014 - 05/2002
10	Collagen Type I (Type I Collagen)IBA 09/2015 - 09/2002
6	Thioacetamide (Thioacetamid)IBA 02/2009 - 02/2004
5	Transforming Growth Factor beta (TGF-beta)IBA 01/2012 - 02/2006
4	Transforming Growth Factors (Transforming Growth Factor)IBA 07/2019 - 03/2013
4	Hydroxyproline (4 Hydroxyproline)IBA 02/2009 - 09/2002
3	Proteins (Proteins, Gene)FDA Link 09/2008 - 09/2004
3	Messenger RNA (mRNA)IBA 06/2008 - 10/2002
2	febrifugineIBA 06/2021 - 07/2019
2	DysferlinIBA 01/2018 - 01/2013
2	AcidsIBA 01/2012 - 02/2008
2	AntibodiesIBA 01/2012 - 05/2002
2	CeruletideIBA 10/2010 - 05/2009
2	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 10/2010 - 09/2008
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 02/2009 - 09/2004
2	CytoglobinIBA 09/2008 - 02/2007
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2008 - 09/2003
2	Matrix Metalloproteinases (MMPs)IBA 04/2006 - 09/2003
1	radixinIBA 03/2017
1	ezrinIBA 03/2017
1	Laminin (Merosin)IBA 03/2017
1	moesinIBA 03/2017
1	UtrophinIBA 09/2015
1	DystrophinIBA 09/2015
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 08/2015
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 08/2015
1	CholesterolIBA 08/2015
1	Amino Acids FDA Link 01/2015
1	prolyl T RNA synthetaseIBA 01/2015
1	GR24 strigolactoneIBA 01/2015
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2015
1	AlkaloidsIBA 06/2012
1	QuinazolinonesIBA 06/2012
1	Green Fluorescent ProteinsIBA 01/2012
1	Angiotensin Receptor AntagonistsIBA 01/2012
1	Losartan (Cozaar)FDA LinkGeneric 01/2012
1	Extracellular Matrix ProteinsIBA 01/2012
1	Angiotensin IIIBA 01/2012
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2012
1	Thiram FDA Link 07/2011
1	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 07/2011
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 07/2011
1	Collagen Type II (Type II Collagen)IBA 07/2011
1	Alkaline PhosphataseIBA 07/2011
1	Interleukin-17 (Interleukin 17)IBA 01/2011
1	matrigelIBA 10/2010
1	JNK Mitogen-Activated Protein KinasesIBA 05/2009
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 02/2009
1	LigandsIBA 02/2009
1	PPAR gammaIBA 02/2009
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 02/2009
1	Rosiglitazone (Avandia)FDA Link 02/2009
1	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 02/2009
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2009
1	EnzymesIBA 09/2008
1	heparanaseIBA 06/2008
1	Proteoglycans (Proteoglycan)IBA 06/2008
1	Collagenases (Collagenase)FDA Link 04/2008
1	Biomarkers (Surrogate Marker)IBA 02/2008
1	CurcuminIBA 04/2007
1	transgelinIBA 02/2007
1	Dactinomycin (Actinomycin)FDA LinkGeneric 02/2007
1	Docetaxel (Taxotere)FDA Link 02/2007

Therapy/Procedure

11	Therapeutics 07/2019 - 06/2002
2	Drug Therapy (Chemotherapy) 01/2012 - 02/2007
1	Oral Administration 01/2012